The oxymorphone in OPANA ER may result in spasm from the sphincter of Oddi. Opioids may bring about will increase in serum amylase. Often Consider sufferers with biliary tract condition, which includes acute pancreatitis, for worsening signs.???? ?????: ?? ?? ????? ??? ???????? ??????? ??????? ????????Tend not to alter your dose. Just take OPANA ER